Harvi Advanced

Harvi-Advanced is intended for students, fellows and postgraduates interested to take a deeper dive into cardiovascular physiology and the hemodynamics of disease and therapeutics. This version includes two textbooks (with additional textbooks in development) and an extensive cardiovascular simulation with the ability to simulate a multitude of common disease states and introduce various therapies, including mechanical support devices.

Watch the Intro Video

$49.99 / year

This license provides access to:

  • Two completed comprehensive textbooks on the basics of cardiovascular physiology, the Student textbook and access to 2 additional advanced books (covering the hemodynamics of common cardiac conditions and mechanical circulatory support) as they become available
  • Advanced cardiovascular simulation with ability to simulate all forms of heart failure, valve diseases, coronary artery disease, understand myocardial energetics and introduce and vary settings of a variety of mechanical support devices and basic set of intravenous pharmacologic agents
  • Extensive Try-It- Now libraries
  • Access a library of prestored clinical cases and examples
  • The Patient Simulator
  • Ability to save, recall and share parameter sets that you create

Features

Textbooks

Part I of the Harvi-Advanced textbook has detailed chapters on

  • Left ventricular (LV) pressure-volume loops
  • Preload
  • Afterload
  • Contractility
  • Diastolic Properties
  • Ventricular-vascular interactions
  • Right ventricular and atrial pressure-volume loops
  • Means of assessing pressure-volume loops (invasive and noninvasive)
  • A Try-it-Now library that illustrate the concepts in each of these chapters.

Part II of the Harvi-Advanced textbook has detailed chapters on

  • Normal Valve Function and Flow Patterns
  • The Pericardium and Ventricular Interactions
  • Excitation-Contraction Coupling
  • Determinants of Myocardial Oxygen Consumption
  • Basics of Myocardial Metabolism
  • Regulation of Coronary Blood Flow
  • Basics of Cardiovascular Receptor Biology and Pharmacology
  • Autonomic Control of the Circulation
  • Exercise Physiology
  • A Try-it- Now library that illustrate the concepts in each of these chapters

Parts III and IV of the Harvi-Advanced textbook series (in development) will cover

  • Cardiovascular pathologies and the hemodynamics
  • Mechanical circulatory support

Simulation Parameters

The Harvi-Advanced simulation gives access to

  • Vary detailed properties of the ventricles, atrial and vascular systems
  • Introduce and vary severity of valve pathologies
  • Introduce and vary severity of common shunts (ASD, VSD, PDA)
  • Introduce and vary left main coronary artery stenosis and learn about coronary autoregulation and the balance between ventricular energy supply and demand
  • Introduce and vary pericardial constraints and effusions
  • Alter the heart rhythm (PACs, VT, AFib)
  • Introduce and vary doses of some frequently used drugs
  • The Patient Simulator, which will adjust simulation parameter values to match a specified hemodynamic profile

Simulation Outputs

Graphical output options include ability to display

  • LV pressure-volume loops
  • Pressure-volume loops of 2 or 4 chambers simultaneously
  • A wide range of continuous signal tracings over time (e.g., blood pressure, pulmonary pressures, blood flow profiles across any cardiac valve, LV and RV pressures and volumes, blood flow profile through
  • shunts)
  • 1, 2 or 3 time plots simultaneously
  • Real-time display of myocardial oxygen consumption and ventricular work
  • Pressure-flow characteristics of different forms of mechanical circulatory support

Numerical output options include ability to display

  • A wide ranges of standard cardiovascular parameters (e.g., blood pressure, pulmonary pressures, cardiac output, LV and RV ejection fractions, volumes and pressures)
  • Cardiac valve characteristics (regurgitant fractions, valve areas, mean and peak pressure gradients)
  • Flows through shunts and Qp:Qs values
  • Mechanical support device flows

Compare Versions of Harvi

Click on a category to see what is included in each version.

Books

    • Student
    • Advanced
    • ECMO
    • Complete
    • Professor
    • Basic Physiological Principles
    • no
    • x
    • no
    • x
    • x
    • Advanced Physiological Principles
    • no
    • x
    • no
    • x
    • x
    • Student - Introduction to Cardiovascular Physiology
    • x
    • x
    • x
    • x
    • x
    • ECMO and the Physiology of Gas Exchange
    • no
    • no
    • x
    • x
    • x
    • Understanding Blood Gases
    • x
    • x
    • no
    • x
    • x

Input Panels

    • Student
    • Advanced
    • ECMO
    • Complete
    • Professor
    • Basic LV
    • x
    • x
    • no
    • x
    • x
    • Basic 4 Chamber
    • x
    • x
    • x
    • x
    • x
    • Ventricles & Pericardium
    • no
    • x
    • no
    • x
    • x
    • Atria
    • no
    • x
    • no
    • x
    • x
    • Valves & Shunts
    • no
    • x
    • x
    • x
    • x
    • Rhythm
    • no
    • x
    • no
    • x
    • x
    • Vessels
    • no
    • x
    • no
    • x
    • x
    • Patient Simulator
    • no
    • x
    • x
    • x
    • x
    • Pharmacology
    • x
    • x
    • x
    • x
    • x
    • Devices
    • no
    • x
    • x
    • x
    • x
    • ECMO
    • no
    • no
    • x
    • x
    • x
    • CardioPulmonary Patient
    • no
    • no
    • x
    • x
    • x
    • ECMO/Patient
    • no
    • no
    • x
    • x
    • x
    • Lung/MVO2/ABG
    • no
    • no
    • no
    • no
    • x
    • IABP
    • no
    • x
    • no
    • x
    • x
    • Scenarios
    • no
    • no
    • no
    • no
    • x
    • CardioPulmonaryBypass
    • no
    • no
    • x
    • x
    • x
    • TEACH
    • no
    • x
    • x
    • x
    • x

Output Panels

    • Student
    • Advanced
    • ECMO
    • Complete
    • Professor
    • Basic
    • x
    • x
    • x
    • x
    • x
    • Hemodynamics
    • x
    • x
    • x
    • x
    • x
    • Valves/Shunts
    • no
    • x
    • no
    • x
    • x
    • Aortic Valve Doppler
    • no
    • x
    • no
    • x
    • x
    • Pulmonary Valve Doppler
    • no
    • x
    • no
    • x
    • x
    • Devices
    • no
    • x
    • no
    • x
    • x
    • Blood Gases
    • no
    • no
    • x
    • x
    • x
    • LV Metabolism
    • no
    • x
    • no
    • x
    • x
    • ECMO
    • no
    • no
    • x
    • x
    • x
    • CPB
    • no
    • no
    • x
    • x
    • x
    • Capture/Hemo
    • x
    • x
    • x
    • x
    • x
    • Capture/ABG
    • no
    • no
    • x
    • x
    • x

Plots

    • Student
    • Advanced
    • ECMO
    • Complete
    • Professor
    • 1 PV Loop & 1 Time Plot
    • x
    • x
    • x
    • x
    • x
    • 1 PV Loop & 2 Time Plots
    • no
    • x
    • x
    • x
    • x
    • 1 PV Loop & 3 Time Plots
    • no
    • x
    • no
    • x
    • x
    • 4 PV Loops & 3 Time Plots
    • x
    • x
    • no
    • x
    • x
    • 2 PV Loops
    • no
    • no
    • no
    • no
    • x
    • 2 PV Loops & 2 Time Plots
    • no
    • no
    • x
    • x
    • x
    • 4 PV Loops
    • no
    • no
    • no
    • no
    • x
    • 6 Time Plots
    • no
    • no
    • no
    • no
    • x
    • Patient Monitor
    • x
    • x
    • x
    • x
    • x
    • Patient Monitor & 1 PV Loop & 1 Time Plot
    • no
    • x
    • no
    • x
    • x
    • Energetics (MVO2-PVA)
    • no
    • x
    • no
    • x
    • x
    • Blood Gases
    • no
    • no
    • x
    • x
    • x
    • Blood Gases & 1 PV Loop & 1 Time Plot
    • no
    • no
    • x
    • x
    • x
    • Blood Gases & 4 PV Loops & 4 Time Plots
    • no
    • no
    • x
    • x
    • x
    • Body
    • no
    • no
    • x
    • x
    • x
    • Body & 1 PV Loop & 1 Time Plot
    • no
    • no
    • x
    • x
    • x
    • Body & 4 PV Loops & 3 Time Plots
    • no
    • no
    • x
    • x
    • x
    • Pump Hemodynamics
    • no
    • x
    • no
    • x
    • x
    • ECMO Monitor
    • no
    • no
    • x
    • x
    • x
    • PV Loop & ECMO Monitor & Patient Monitor
    • no
    • no
    • x
    • x
    • x
    • Body & ECMO Monitor & Patient Monitor
    • no
    • no
    • x
    • x
    • x
    • ABG & ECMO Monitor & Patient Monitor
    • no
    • no
    • x
    • x
    • x
    • CardioPulmonary Bypass
    • no
    • no
    • no
    • no
    • x
    • CardioPulmonary Bypass & 4 PV Loops & 4 Time Plots
    • no
    • no
    • no
    • no
    • x
    • CardioPulmonary Bypass & Blood Gases
    • no
    • no
    • no
    • no
    • x
    • CardioPulmonary Bypass & Patient Monitor
    • no
    • no
    • x
    • x
    • x
    • CardioPulmonary Bypass & 4 PV Loops & 1 Time Plot & Blood Gases
    • no
    • no
    • no
    • no
    • x

Display and Download Tools

    • Student
    • Advanced
    • ECMO
    • Complete
    • Professor
    • Signal Recording
    • no
    • no
    • no
    • no
    • x
    • End of Beat Input & Output Recording
    • no
    • no
    • no
    • no
    • x
    • Auxiliary Plot Windows
    • no
    • no
    • no
    • no
    • x